How to tes5edit

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I learned from the tutorials how to clean identical green files, but now what to do with the reds? I read and watched tutorials, but im having the problem they didnt explain what i have to do with the red lines, just what the background and text color stand for. I already cleaned the master files update/dawnguard/hearthfire watching a tutorial. I don't have any crashes with skyrim, but they still recommend it.

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I want to use tes5edit, cause many recommend it.